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SUMMARY:Understanding and manipulating CNS remyelination - in mouse\, man 
 and zebrafish. - Dr Anna Williams\, University of Edinburgh\, MRC Centre f
 or Inflammation Research
DTSTART:20140129T161500Z
DTEND:20140129T171500Z
UID:TALK49172@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Central nervous system (CNS) remyelination is inefficient in m
 an\, restricting recovery from demyelinating diseases such as multiple scl
 erosis. Post mortem MS tissue gives us a limited window into the mechanism
  of this\, but means that we need to use other animal models. Rodent CNS r
 emyelination is more efficient\, especially in young rodents\, with virtua
 lly complete remyelination in extent\, though the myelin sheaths remain th
 in and short. These rodent models  can be manipulated to change the effici
 ency of remyelination\, allowing identification of potential therapeutic t
 argets but also perhaps modelling human disease better. Zebrafish are gene
 rally very regenerative organisms\, and I will discuss how efficiently the
 y carry out CNS remyelination\, and what differences between zebrafish\, r
 odent and human may teach us about remyelination biology.
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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