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SUMMARY:Structural insights into the molecular mechanisms of accurate chro
 mosome segregation. - Dr. A. Jeyaprakash Arulanandam\, Wellcome Trust Cent
 re for Cell Biology\, University of Edinburgh
DTSTART:20140116T143000Z
DTEND:20140116T153000Z
UID:TALK49220@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Accurate chromosome segregation involves highly orchestrated m
 itotic events such as chromosome condensation\, attachment of microtubules
  to the sister chromatids via the kinetochores\, movement of sister chroma
 tids towards the spindle poles and cytokinesis. Such a complicated network
  of events that takes place between the onset and exit of mitosis is regul
 ated by a number of molecular assemblies (including condensin\, cohesin\, 
 Chromosomal Passenger Complex (CPC)\, KMN (Knl1-Mis12-Ndc80) network\, Ska
  complex\, spindle checkpoint assembly and the anaphase promoting complex)
  involving an extensive network of protein-protein interactions. \n\nAmong
  the key molecular interactions\, those involving the CPC and the Ska comp
 lex are currently being investigated in our lab\, mainly due to their esse
 ntial role in kinetochore-microtubule attachments and in timely mitotic pr
 ogression. While the CPC\, with its enzymatic core Aurora B kinase\, orche
 strates various mitotic events from chromosome condensation to cytokinesis
  by phosphorylating the right substrate at the right place and time\, the 
 Ska complex physically couples chromosomes to the spindle MTs by interacti
 ng with KT-associated proteins and is implicated in the timely onset of an
 aphase. During the talk\, I will be discussing our efforts to understand t
 he structural and functional role of these protein complexes in achieving 
 accurate cell division. 
LOCATION:Part II Room\, Department of Genetics
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