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SUMMARY:It takes two to tango: The cerrebellum simplified into two types o
 f modules with two encoding schemes - Professor Chris de Zeeuw. Erasmus MC
 \, Rotterdam and the Netherands Institute for Neuroscience\, Amsterdam
DTSTART:20140203T163000Z
DTEND:20140203T180000Z
UID:TALK49320@talks.cam.ac.uk
CONTACT:P.H. Marchington
DESCRIPTION:1.Gao et al.\, 2012 Nature Reviews and De Zeeuw et al.\, 2011 
 Nature Reviews\n\n2.Detlef\, H. H. & De Zeeuw\, C. I. et al.\, J Neuroscie
 nce 2013. \n\n3. Detlef\, H.H.\, De Zeeuw\, C.I.\, Jaeger\, D.\, Khodakhan
 \, K.\, & Person\, A.L. 2013 The Neuronal Code(s) of the Cerebellum. The J
 ournal of Neuroscience. 33(45): 17603-17609\; doi: 10. 1524/jNeuroscience.
  2757-13. 2013.\n\nAbstract\nUnderstanding how neurons encode information 
 in sequences of action potentials is of fundamental importance to neurosci
 ence. The cerebellum is widely recognized for its involvement in the coord
 ination of movements\, which requires muscle activation patterns to be con
 trolled with millisecond precision. Understanding how cerebellar neurons a
 ccomplish such high temporal precision is critical to understanding cerebe
 llar function. Inhibitory Purkinje cells\, the only output neurons of the 
 cerebellar cortex\, and their postsynaptic target neurons in the cerebella
 r nuclei\, fire action potentials at high\, sustained frequencies\, sugges
 ting spike rate modulation as a possible code. Yet\, millisecond precise s
 patiotemporal spike activity patterns in Purkinje cells and inferior oliva
 ry neurons have also been observed. These results and ongoing studies sugg
 est that the neuronal code used by cerebellar neurons may span a wide time
  scale from millisecond precision to slow rate modulations\, likely depend
 ing on the behavioral context.\n
LOCATION:Hodgkin-Huxley Room\, Department of Physiology Development and Ne
 uroscience
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