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SUMMARY:Chasing metabolic alterations in cancer - Dr Arkaitz Carracedo\, C
 IC bioGUNE\,  (Center for Cooperative Research in Biosciences)\, Derio\, S
 pain
DTSTART:20140107T120000Z
DTEND:20140107T130000Z
UID:TALK49447@talks.cam.ac.uk
CONTACT:Dr Ireena Dutta
DESCRIPTION:From a formal scientific perspective\, neoplastic transformati
 on could be considered the reflection of the power of evolution for a fund
 amental scientist.  The acquisition of mutations\, clonal selection and ev
 olution make tumors dynamic entities in a continuum of heterogeneity. In a
 ddition to intrinsic determinants (mutations)\, cancer cells also acquire 
 behavioral changes in response to the hostile environment where they inhab
 it or land\, which profoundly affects their fate. The highways connecting 
 DNA alterations\, extracellular changes and cell fate decisions stem from 
 two plastic communication networks: cellular signaling and metabolic pathw
 ays. The idiosyncrasies of cancer metabolism were first noted by Otto Warb
 urg in the nineteen twenties but the concept would not be rescued until th
 e past decade. Together\, cancer cell signaling and metabolism are the exe
 cutors of many of the observed cancer mutations\, providing cancer cells w
 ith the power to proliferate\, survive to stress\, and disseminate to dist
 al organs.  In this seminar\, I will overview how alterations in cancer ge
 nes impact on metabolism and conversely\, how metabolic mediators can be r
 evealed as potential targets for cancer therapy. 
LOCATION:Sackler Lecture Theatre (Level 7)\, Cambridge Institute for Medic
 al Research
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