BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Cortical HCN channels: function\, trafficking and plasticity - Dr 
 Mala Shah\; Department of Pharmacology\, UCL School of Pharmacy
DTSTART:20140306T160000Z
DTEND:20140306T170000Z
UID:TALK49729@talks.cam.ac.uk
CONTACT:Philipe Mendonca
DESCRIPTION:The hyperpolarization-activated cyclic nucleotide gated (HCN) 
 channels are voltage-gated ion channels that are active at rest and are im
 portant for determining the intrinsic membrane properties of neurons. Four
  HCN subunits (HCN1-4) have been cloned\, with HCN1 predominantly expresse
 d in the cortex. These subunits are abundant in cortical pyramidal neuron 
 dendrites but can also be located in synaptic terminals and axons. In this
  lecture\, I will highlight our findings on the involvement of these chann
 els in dendritic excitability\, synaptic release and epileptogenesis in th
 e entorhinal cortex (EC)\, an area of the brain involved in normal physiol
 ogical processes such as spatial navigation and cognition as well as patho
 physiological conditions such as epilepsy. I will also present our data on
  the distinct molecular mechanisms underlying trafficking of these channel
 s to dendritic and pre-synaptic compartments. This lecture should\, thus\,
  provide an insight into the role of these channels in regulating cortical
  neuronal function and the potential consequences of this for cognition an
 d epilepsy.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
END:VEVENT
END:VCALENDAR