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SUMMARY:Regulation of lymphocyte development and activation by RNA binding
  proteins and non-coding RNA - Dr Martin Turner\; Laboratory of Lymphocyte
  Signalling and Development\, The Babraham Institute
DTSTART:20140313T160000Z
DTEND:20140313T170000Z
UID:TALK49730@talks.cam.ac.uk
CONTACT:Philipe Mendonca
DESCRIPTION:The rapid changes in gene expression that accompany developmen
 tal transitions\, stress responses and proliferation are controlled by sig
 nal-mediated co-ordination of transcriptional and post-transcriptional mec
 hanisms. The synthesis of new RNA with the capacity to encode proteins or 
 with regulatory potential is a keystone event in these processes.   Of equ
 al importance is the regulation of RNA stability and localisation (on tran
 slating ribosomes or elsewhere in the cell).   Thus the dynamics of gene e
 xpression involve the integration of transcription and post-transcriptiona
 l control by signal transduction networks. Understanding the mechanics of 
 these processes and the contexts in which they are employed during haemato
 poiesis and immune challenge is a goal towards which important progress ha
 s been made in recent years. A significant aspect of the progress is the r
 ecognition of the importance of non-coding RNA in the development and func
 tion of the immune system.  Non-coding RNA includes microRNAs\, but also t
 he untranslated regions of messenger RNAs which function by binding microR
 NAs and also proteins which recognise specific sequences or secondary stru
 ctures. I will discuss specific examples of post-transcriptional control i
 n the regulation of lymphocytes development and activation.\n \nMartin Tur
 ner was a PhD student with Marc Feldmann where he studied the regulation o
 f cytokine gene expression. Amongst these studies was the observation that
  TNF induced IL-1\, a basic finding that contributed to the rationale of a
 nti-TNF therapy.  Next\, with Victor Tybulewicz he applied mouse genetics 
 to understand the signaling mechanisms of the lymphocyte antigen receptors
 .  This work highlighted the roles of the kinase Syk and of Vav1.  Subsequ
 ently\, he has identified roles for phosphoinositide 3-kinase (PI3K) pathw
 ays in lymphocyte development and function.  He has published key studies 
 on the role of P110delta in B lymphocyte signalling pathways.  These studi
 es have contributed to the knowledge base underpinning the successful use 
 of isoform-selective PI3Kdelta inhibitors in the clinic for the treatment 
 of chronic lymphocytic leukaemia.  He has pioneered the investigation of p
 ost-transcriptional regulation of lymphocyte development function identify
 ing physiological roles for microRNAs and RNA binding proteins (RBPs) in t
 he differentiation of B and T lymphocytes. These studies have also provide
 d clear evidence for a tumour suppressor role mediated by RBPs.\n
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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