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SUMMARY:G-quadruplex: the DNA quadruple helix - Professor Shankar Balasubr
 amanian FMedSci FRS (CRUK and Department of Chemistry\, University of Camb
 ridge)
DTSTART:20140312T190000Z
DTEND:20140312T203000Z
UID:TALK49740@talks.cam.ac.uk
CONTACT:Ivan Lam
DESCRIPTION:_This talk is free for members of BioSoc or £2 for non-member
 s. You can also sign up for life membership (£15) at this talk._\n\nDNA i
 s structurally dynamic in ways that have a consequence for biological proc
 esses.  In this lecture I will discuss a class of four-stranded DNA struct
 ure\, called the G-Quadruplex that can be formed from G-rich single strand
 ed DNA.  There is now a good level of understanding on the structural biop
 hysics of G-quadruplexes along with a large body of work on the design and
  synthesis of small organic molecules that can target such structures.  So
 me such molecules have been found to have anti-proliferative effects on hu
 man cancer cells along with specific effects on the activity of certain ge
 nes\, raising intriguing hypotheses about their existence and function in 
 cells.  I will present recent results from my laboratory that provide new 
 insights into when and where such non-Watson-Crick structures may exist in
  cellular DNA together with a perspective on whether this structural motif
  in DNA presents new opportunities to think about intervention and future 
 therapeutics.
LOCATION:Wolfson Lecture Theatre\,  Department of Chemistry
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