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SUMMARY:Spiking irregularity in cortical inhibitory interneurons - Philipe
  Mendonca\, Department of Physiology\, Development and Neuroscience\, Univ
 ersity of Cambridge
DTSTART:20140220T130000Z
DTEND:20140220T140000Z
UID:TALK50209@talks.cam.ac.uk
CONTACT:Aleksandr Sahakyan
DESCRIPTION:Excitatory Pyramidal Neurons (PN) are the main output source o
 f the Neocortex. These cells are affected by the activity of Interneurons\
 , which  display a striking variety of morphologies\, neuropeptides\, and 
 spiking patterns. The Irregular Spiking (IS) interneuron is of particular 
 interest\, displaying a dispersed spiking time when stimulated in vitro\, 
 even when synapses are blocked. It could be said that IS interneurons add 
 randomness to the cortical network. The relevance of this irregularity is 
 still unclear.\nThis work aims to address the mechanism and function of th
 is irregularity. We first recorded a population of rat cortical neurons an
 d showed that IS cells only display abnormal interspike intervals (ISI) at
  frequencies below 15hz. Voltage clamp recordings of IS cells presented a 
 prominent fast transient outward current that may be involved in this intr
 insic irregularity.\nWe are next addressing whether this irregularity is i
 nfluenced by cell morphology via cell dissociation. Future prospects inclu
 de morphological reconstruction and double whole-cell patch clamp to bette
 r understand how IS cells synchronise with each other.\n
LOCATION:Entertaining Room\, Darwin College
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