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SUMMARY:Cyclofluidic: Quick hit-to-lead optimization using an integrated m
 icrofluidic approach  - Dr Ronald Dorenbos\, Business Development Director
  Europe Cyclofluidic Ltd.
DTSTART:20140205T101500Z
DTEND:20140205T111500Z
UID:TALK50252@talks.cam.ac.uk
CONTACT:23791
DESCRIPTION:Small molecule lead discovery involves an iterative process of
  molecular design\, chemical synthesis\, biological assay and data analysi
 s to feed into the next learning cycle. The Cyclofluidic technology platfo
 rm CyclOps™ integrates all the processes key to medicinal chemistry on t
 he bench-top\, allowing drug lead molecules to be assayed minutes (rather 
 than weeks) after they are designed. CyclOps™ connects flow chemistry\, 
 purification\, screening and drug design with complex algorithms developed
  in collaboration with Accelerys. Each potential lead molecule is synthesi
 sed\, purified and screened in fast serial mode\, incorporating activity d
 ata from every iteration into the algorithm for the selection of the next 
 compound to make. Cyclofluidic’s technology platform CyclOps™ is based
  on ground breaking research developed in the laboratories of Professor St
 eve Ley at Cambridge University and at GlaxoSmithKline. The power of the p
 latform was recently demonstrated with the rapid generation of structure a
 ctivity relationship (SAR) data around Abl Kinase inhibitors\, which led t
 o the identification of 4 novel potent inhibitor molecules that had not be
 en described before in any patents or literature.   \n\nSelected Reference
 s:\n1)	Desai B\, Dixon K\, Farrant E\, Feng Q\, Gibson KR\, van Hoorn WP\,
  Mills J\, Morgan T\, Parry DM\, Ramjee MK\, Selway CN\, Tarver GJ\, Whitl
 ock G\, Wright AG. (2013). Rapid discovery of a novel series of Abl kinase
  inhibitors by application of an integrated microfluidic synthesis and scr
 eening platform. J Med Chem.\, 56(7)\, 3033-47. \n2)	Werngard Czechtizky\,
  Jüergen Dedio\, Bimbisar Desai\, Karen Dixon\, Elizabeth Farrant\, Qixin
 g Feng\, Trevor Morgan\, David M. Parry\, Manoj K. Ramjee\, Christopher N.
  Selway\, Thorsten Schmidt\, Gary J. Tarver\, and Adrian G. Wright. (2013)
 . Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhi
 bitors: Application to Drug Discovery. ACS Med. Chem. Lett.\, 4(8)\, 768
 –772.\n\n
LOCATION:Biochemistry Seminar Room\, Sanger Building
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