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SUMMARY:Tracking proteins inside cells - Dr Laurent Gatto (University of C
 ambridge)
DTSTART:20140130T174500Z
DTEND:20140130T193000Z
UID:TALK50387@talks.cam.ac.uk
CONTACT:21255
DESCRIPTION:In biology\, localisation is function. Cells display a complex
 \nsub-cellular structure with numerous distinct niches responsible for\nsp
 ecific biological processes. Consequently\, not only must proteins be\npre
 sent to accomplish their biological functions\, but they must be\nlocalise
 d at their intended sub-cellular locations. In contrast\,\nmislocalised pr
 oteins can have serious advert consequences. We will\nreview and understan
 d how contemporary experimental and computational\ntechnologies can be use
 d to create sub-cellular localisation maps for\nthousands of proteins.\n\n
 Suggested reading\n\nGeneral background:\n1. Wikipedia cell article\, in p
 articular the subcellular components section\n2. Wikpedia protein article\
 , in particular the cellular localization section\n\nRelevant reviews:\n3.
  Yan et al. 2009\n4. Gatto et al. 2010\n\nSoftware:\n5. pRoloc - A unifyin
 g bioinformatics framework for organelle proteomics\n\n[1] http://en.wikip
 edia.org/wiki/Cell_(biology)\n[2] http://en.wikipedia.org/wiki/Protein\n[3
 ] http://www.ncbi.nlm.nih.gov/pubmed/19110081\n[4] http://www.ncbi.nlm.nih
 .gov/pubmed/21080489\n[5] http://www.bioconductor.org/packages/devel/bioc/
 html/pRoloc.html
LOCATION:Old Combination Room\, Trinity College
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