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SUMMARY:Generating order from chaos: harnessing noise and heterogeneity in
  the evolution of robust developmental patterning - Chris Thompson (Univer
 sity of Manchester)
DTSTART:20140225T174500Z
DTEND:20140225T193000Z
UID:TALK50393@talks.cam.ac.uk
CONTACT:21255
DESCRIPTION:Embryonic development is a remarkable feat of biological repro
 ducibility.  This is despite the fact that the molecular processes that un
 derlie developmental mechanisms are actually rather noisy\, variable\, or 
 even stochastic. For many years\, the prevailing idea has thus been that n
 oise must be dampened. However\, recent observations of simple microbial s
 ystems challenge this idea\, and even suggest stochastic heterogeneity or 
 noise in cell signalling and responses can be evolutionarily advantageous.
   Together\, these findings have huge implications\, because they raise th
 e question of whether heterogeneity plays a role in cell fate choice and d
 evelopmental patterning in higher organisms. In this talk I will describe 
 our progress in understanding this question through the identification of 
 'lineage priming' genes and will discuss its implications for regenerative
  medicine.\nhttp://elife.elifesciences.org/content/2/e01760
LOCATION:Winstanley Lecture Theatre
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