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SUMMARY:Watching single molecules - Dr David Klenerman\, Department of Che
 mistry\, Cambridge University
DTSTART:20140124T150000Z
DTEND:20140124T160000Z
UID:TALK50444@talks.cam.ac.uk
CONTACT:36430
DESCRIPTION:For about the last 15 years it has been possible to directly o
 bserve individual molecules in solution\, attached to surfaces or in the m
 embrane of live cells.My group has focussed on developing these methods an
 d applying them to biological or biomedical problems\, which have been dif
 ficult or impossible to solve using more conventional bulk methods. I will
  firstly introduce scanning ion conductance microscopy\, which allows nano
 scale imaging of live cells and controlled delivery of molecules to the ce
 ll surface. Next I will show how we have developed single molecule fluores
 cence to detect the interaction of molecules in the test-tube and on cells
 . I will then show how these methods can be used to gain new molecular ins
 ights by describing our recent work on T-cell triggering and the role of p
 roteins aggregates in neurodegenerative disease.\nHost: Michel Goedert
LOCATION:Max Perutz Lecture Theatre\, MRC Laboratory of Molecular Biology
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