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SUMMARY:The Human Green Brain Project: Computational Models of the Develop
 ing Connectome - Marcus Kaiser\, Newcastle University\, UK
DTSTART:20140429T100000Z
DTEND:20140429T110000Z
UID:TALK50455@talks.cam.ac.uk
CONTACT:Mikail Rubinov
DESCRIPTION:The human brain consists of connections between neurons at the
  local level and of connections between brain regions at the global level.
  The study of the entire network\, the connectome\, has become a recent fo
 cus in neuroscience research. Recent advances in neuroimaging\, using diff
 usion tensor imaging\, allow us to observe how the human brain network dif
 fers over ages ranging from the embryonic to the adult stage. In the Human
  Green Brain Project (http://www.greenbrainproject.org/)\, which started i
 n October 2013\, we analyse how the human brain network arises during deve
 lopment by combining data analysis with simulations of brain development. 
 Objectives are to develop a simulation of human brain development\, to ana
 lyse network features of human brains at different developmental stages\, 
 and to compare simulations with real data to discover the underlying mecha
 nisms for brain network development. Simulations are crucial to study the 
 role of different developmental parameters on the final brain network as w
 ell as on intermediate networks during development. We present how the net
 work organisation of the brain is changing during evolution and for human 
 ontogentic development. We find while connections are reduced during devel
 opment (10-40 years)\, this process spares long-distance connections that 
 are crucial for information integration. Furthermore\, this process of con
 nection refinement starts earlier in girls than in boys. Finally\, we will
  present computational models that can account for some of the changes tha
 t are seen during network development.
LOCATION:MRC CBU lecture theatre\, 15 Chaucer Road
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