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SUMMARY:Investigation of the molecular mechanisms of Minute competition in
  Drosophila - Iwo Kucinski (University of Cambridge)
DTSTART:20140124T163000Z
DTEND:20140124T170000Z
UID:TALK50467@talks.cam.ac.uk
CONTACT:30967
DESCRIPTION:Cell competition is a process\, during which a fitter cell pop
 ulation outcompetes a population of neighbouring weaker cells\, through th
 eir elimination or growth rate regulation. Despite discovery 35 years ago 
 our knowledge about the molecular mechanisms governing cell competition is
  very limited. In particular little is known about the mechanism that earm
 arks weaker cells as losers and about the initial signals that trigger cel
 l competition.\nIn order to identify the molecular signature of loser cell
 s in Drosophila wing discs we used a transcriptional profiling approach. W
 e generated and analysed RNAseq data for different loser mutants (differen
 t Minute mutations and mahj) and winner population (wt cells). Surprisingl
 y two different types of cell competition (induced by Minute and mahj muta
 tions) have very similar transcriptional profiles. As this signature might
  be directly involved in cell competition\, we will investigate this issue
  further and determine which of the processes determine the loser identity
  of a cell.\n
LOCATION:Tea Room\, Department of Zoology
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