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SUMMARY:Tackling transgeneration risk for type 2 diabetes in Sub-Saharan A
 frica (King's/Cambridge-Africa Seminar) - Professor David Dunger\, Head of
  the Department of Paediatrics\, University of Cambridge
DTSTART:20140311T180000Z
DTEND:20140311T190000Z
UID:TALK50472@talks.cam.ac.uk
CONTACT:Dr Pauline Essah
DESCRIPTION:The worldwide increase in the incidence of type 2 diabetes (T2
 D) is falling disproportionately on transitioning societies\, where histor
 ically nutrition has been poor\, but recent changes have led to increased 
 food availability and reduced exercise levels.  As well as the obesity rel
 ated T2D risk associated with these demographic changes there is also evid
 ence of transgenerational risk for T2D.  Low birth weight and early stunti
 ng may be followed by adolescent obesity and increased risk for gestationa
 l diabetes.  Increased glucose exposures during fetal development may incr
 ease risk of obesity\, insulin resistance and T2D in the next generation. 
  This vicious cycle may accelerate T2D prevalence across generations.\n\nO
 ur collaborations with University of Witswatersrand involves detailed eval
 uation of growth and metabolism and exploration of epigenetic mechanisms w
 hich may underpin transgenerational risk for T2D\, across the three genera
 tions recruited to the Birth to Twenty (Bt20) cohort in Soweto.  Through e
 xtensive field work in the more rural Mpumalanga province of South Africa 
 we have developed a complex intervention around pre-pregnancy and pregnanc
 y weight gain with the aim of reducing transgenerational risk for T2D (Nts
 hembo).  This clustered randomised controlled trial will explore whether l
 ocal health worker based interventions can be effective in reducing risk f
 or metabolic disease in transitioning societies.\n
LOCATION:Wine Room\, King's College\, Cambridge\, CB2 1ST
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