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SUMMARY:The Ribosome Flow Model: Theory and Applications - Michael Margali
 ot\, School of Electrical Engineering\, Tel-Aviv University
DTSTART:20140220T140000Z
DTEND:20140220T150000Z
UID:TALK50518@talks.cam.ac.uk
CONTACT:Tim Hughes
DESCRIPTION:The Ribosome Flow Model (RFM) is a set of ordinary differentia
 l equations modeling the movement of interacting particles along a chain o
 f sites. The movement is unidirectional and satisfies a simple exclusion p
 rinciple\, that is\, the particles are assumed to have volume and can bloc
 k each other\, leading to “traffic jams.”\n\nReuveni et al. (2011) use
 d the RFM as a model for translation-elongation. This is a crucial biologi
 cal process in which ribosomes move along the mRNA chain and decode it to 
 produce the corresponding proteins. However\, the RFM can also be used to 
 model and study numerous other natural and artificial processes\, includin
 g vehicles moving along a highway and data packets sent along a serial cha
 in of buffers.\n\nIn this talk\, we describe the analysis of the RFM using
  tools from systems and control theory. We prove that the dynamics converg
 es to a unique steady-state\; entrains to periodic transition rates\; and 
 that the steady-state output (or protein production) rate is a concave fun
 ction of the model parameters.\n\nWe present several biological implicatio
 ns of the analysis and compare them to known experimental results.\n\nJoin
 t work with Tamir Tuller (Tel Aviv University) and Eduardo D. Sontag (Rutg
 ers University)
LOCATION:Cambridge University Engineering Department\, LR11
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