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SUMMARY:Low Cost Bioreactor Design for Bone Tissue Engineering - Mark Varl
 ey
DTSTART:20140211T143000Z
DTEND:20140211T150000Z
UID:TALK50565@talks.cam.ac.uk
CONTACT:Anna Walczyk
DESCRIPTION:In vitro\, 3D cultures are limited by oxygen and nutrient diff
 usion rates resulting in necrosis at the centre of large scaffolds.  Mass 
 transport in these cultures can be controlled to a large extent by use of 
 dynamic bioreactors.  The bioreactor configuration and operation is import
 ant in the success of the culture.  Previous work has showed biaxial rotat
 ion was more successful for in vitro tissue generation than single axis bu
 t did not describe the mechanism underlying this effect.\n\nIn this presen
 tation\, a description of the current state of the bioreactor field for bo
 ne growth is described before the key design requirements of a new low cos
 t design are identified.  Finally to investigate the parameters that are c
 ritical when designing a rotating bioreactor\, two low-cost\, adaptable an
 d open source bioreactor systems are presented and control systems verifie
 d for rotational and positional control. 
LOCATION:Cambridge University Engineering Department\, Oatley meeting room
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