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SUMMARY:Ligand detection and discrimination by spatial relocalisation: the
  complexities of T cell activation - Nigel Burroughs (Dept of Mathematics\
 , University of Warwick)
DTSTART:20060628T160000Z
DTEND:20060628T170000Z
UID:TALK5059@talks.cam.ac.uk
CONTACT:Matthew Levin
DESCRIPTION:We analyse a theory of ligand triggering based on receptor rel
 ocation to regions of low phosphatase activity. The application is cell:ce
 ll communication and receptors where there is no known conformation change
 \, but possessing short ectodomains. Through spatial segregation of long a
 nd short bonds/molecules in the cell:cell interface\, large phosphatases c
 an be excluded from regions of close contact. In these regions small recep
 tors get trapped by binding to their ligands. We examine the sensitivity a
 nd specificity of such as system using a spatial lattice model and molecul
 e diffusion and the requirements for it to have efficient detection charac
 teristics.
LOCATION:Part 2 Seminar Room (First Floor)\, Craik-Marshall Building
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