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SUMMARY:Biomimetic routes to colloidal self-assembly - Jasna Burjic\, NYU\
 , Physics and Soft Matter Center
DTSTART:20140214T140000Z
DTEND:20140214T150000Z
UID:TALK50712@talks.cam.ac.uk
CONTACT:Alessio Zaccone
DESCRIPTION:We designed biomimetic emulsions that are stabilized with a fl
 uid monolayer of\nphospholipids. Grafting DNA onto the liquid interfaces o
 f these oil droplets\nleads to exciting new architectural possibilities du
 e to the mobility of the\nDNA ligands on the surface. We produce two compl
 ementary emulsions: the first\none is dyed in red and functionalized with 
 S sticky ends\; the second\, dyed in\ngreen\, displays the complementary S
 ’ sticky end. Mixing those emulsions reveals\nstrong\, reversible and sp
 ecific adhesion between the complementary emulsions\ndue to the short-rang
 e S-S’ hybridization. The fluidity of the binders on the\nsurface leads 
 to diffusive adhesion patches\, which allows the bound droplets to\nrearra
 nge throughout the packing structure. Furthermore\, controlling the number
 \nof binders on the surface allows us to determine the number of adhesions
  that\ncan be formed between droplets\, i.e. their valence v. We thus prod
 uce doublets\nfor v=1\, flexible chains for v=2 and compact structures of 
 higher valences. The\nvalence and geometry of bonds can also be controlled
  through the use of patchy\nparticles. To this aim we use immiscible mixtu
 res of lipids that spontaneously\ndecompose into domains on the droplets s
 urface\, creating various patterns that\ncan be stable over weeks. We expl
 ore the origin of this stability\, which in\nturn will help us control the
  number and size of functionalized patches on each\ndroplet. Combining tho
 se two approaches this emulsion system will open the\nroute to directed se
 lf-assembly of complex structures through distinct DNA\nbonds with varying
  strengths and controlled valence and flexibility.
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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