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SUMMARY:The Structure of the Large Subunit of the Yeast Mitochondrial Ribo
 some - Dr Alan Brown
DTSTART:20140402T091500Z
DTEND:20140402T101500Z
UID:TALK50842@talks.cam.ac.uk
CONTACT:23791
DESCRIPTION:Mitochondria have specialised ribosomes that have diverged gre
 atly from their bacterial and cytoplasmic counterparts. We have solved the
  structure of the large subunit from the yeast mitochondrial ribosome usin
 g single particle cryo-electron microscopy (cryo-EM) to an overall resolut
 ion of 3.2 Angstroms. A nearly complete atomic model has been built de nov
 o and refined and consists of a total of 39 proteins\, 13 of which are uni
 que to yeast mitochondrial ribosomes\, as well as many expansions of ribos
 omal RNA. The structure reveals a new exit tunnel path and architecture\, 
 unique elements of the ribosomal E site and a putative membrance-facing pr
 otuberance. The talk will also describe new tools that were developed for 
 the interpretation\, refinement and validation of cryo-EM density maps at 
 high resolution. 
LOCATION:Biochemistry Seminar Room\, Sanger Building
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