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SUMMARY:Type VI Secretion System: structure\, function and dynamics of a m
 ulticomponent nanomachine that is evolutionarily related to a contractile 
 phage tail  - Marek Basler\, University of Basel 
DTSTART:20140226T161500Z
DTEND:20140226T171500Z
UID:TALK50974@talks.cam.ac.uk
CONTACT:Anna Davies
DESCRIPTION:Secretion systems allow bacteria to transport macromolecules s
 uch as proteins into host cells during pathogenesis or bacterial cells dur
 ing competition in various ecological settings. Type VI Secretion Systems 
 (T6SS) are encoded by a cluster of 15-20 genes that is present in at least
  one copy in approximately 25% of all sequenced Gram-negative bacteria. Se
 veral T6SS components are structural homologs of components of a contracti
 le bacteriophage tail and assemble into a large structure that can be stud
 ied using whole cell electron cryo tomography and live cell fluorescence m
 icroscopy. A combination of these techniques allows to obtain high resolut
 ion structure of T6SS in situ and to follow T6SS assembly in time. This pr
 ovides an unprecedented level of understanding of this dynamic nanomachine
 . I will discuss structure\, function and dynamics of T6SS in various mode
 l organisms as well as a mechanism of T6SS activation and substrate delive
 ry. \n
LOCATION:Max Perutz Lecture Theatre\, MRC LMB
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