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SUMMARY:Clonally transmissible cancers in dogs and Tasmanian devils - Eliz
 abeth Murchison\, Department of Veterinary Sciences
DTSTART:20140307T130000Z
DTEND:20140307T140000Z
UID:TALK50994@talks.cam.ac.uk
CONTACT:Dr Tennie Videler
DESCRIPTION:The Tasmanian devil facial tumour disease (DFTD) and the canin
 e transmissible venereal tumour (CTVT) are the only two known naturally oc
 curring clonally transmissible cancers. These cancers are spread by the ph
 ysical transfer of living cancer cells between unrelated individuals. DFTD
  is spread by biting and is threatening its host species\, the Tasmanian d
 evil\, with extinction. CTVT is a sexually transmitted cancer affecting do
 mestic dogs that first arose more than ten thousand years ago and has spre
 ad around the world together with its host. A remarkable feature of transm
 issible cancers is their ability to escape their hosts’ immune systems d
 espite their status as allogeneic grafts. I will review the current unders
 tanding of the mechanisms of DFTD and CTVT immune evasion and will discuss
  insights revealed by \n
LOCATION:MPLT\, MRC-LMB\, Francis Crick Avenue\, Cambridge Biomedical Camp
 us\, CB2 0QH
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