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SUMMARY:Modelling the Drosophila pair-rule gene system - Erik Clark
DTSTART:20140221T163000Z
DTEND:20140221T170000Z
UID:TALK51115@talks.cam.ac.uk
CONTACT:30967
DESCRIPTION:During the first few hours of development\, the trunk of the D
 rosophila embryo becomes subdivided into 14 parasegments. This process\, g
 overned by a hierarchical cascade of different classes of segmentation gen
 es\, is one of the most famous textbook examples of developmental pattern 
 formation. The first periodically expressed (stripy) genes are the pair-ru
 le genes\, which are initially expressed with double-segment periodicity. 
 This surprising 'pair-rule' mode of patterning appears to be a derived fea
 ture of insects\, since pair-rule gene expression is only ever segmental i
 n most other arthropods.\n\nThe pair-rule genes regulate each other\, lead
 ing to dynamic expression patterns and a transition from double- to single
 -segment periodicity. However\, despite a long history of experimental wor
 k\, this regulatory system has received little attention from modellers an
 d is the least well-understood part of the segmentation cascade. I will be
  talking about a computational model of the pair-rule system I have been w
 orking on during my PhD so far\, and how it has helped generate testable h
 ypotheses about pair-rule patterning.\n
LOCATION:Tea Room\, Department of Zoology
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