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SUMMARY:Centromere identity and the nature of the chromatin containing the
  variant histone\, CENP-A - BEN E. BLACK\, Ph.D\, Associate Professor of B
 iochemistry and Biophysics\, University of Pennsylvania\, USA
DTSTART:20140430T093000Z
DTEND:20140430T103000Z
UID:TALK51134@talks.cam.ac.uk
CONTACT:Simon Elsaesser
DESCRIPTION:Dr. Ben Black's laboratory is interested in how particular pro
 teins direct accurate chromosome segregation at mitosis. In humans\, the c
 hromosomal element—the centromere—that directs this process is not def
 ined by a particular DNA sequence. Rather\, the location of the centromere
  is dictated by an epigenetic mark generated by one or more resident prote
 ins. These centromeric proteins interact directly with the DNA to create a
  specialized chromatin compartment that is distinct from any other part of
  the chromosome. By taking biophysical\, biochemical\, and cell biological
  approaches\, our work is to define the composition and physical character
 istics of the protein and protein/DNA complexes that epigenetically mark t
 he location of the centromere on the chromosome. This work involves buildi
 ng centromeric chromatin from its component parts for analysis of its phys
 ical characteristics\, developing biochemical assays to reconstitute steps
  in the process of establishing and maintaining the epigenetic mark\, and 
 using cell-based approaches to study the behavior of proteins involved in 
 centromere inheritance and function.
LOCATION:Max Perutz Lecture Theatre\, New MRC-LMB (Addenbrooke's site)
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