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SUMMARY:Revisiting the use of families in complex genetic disease studies 
 - Professor Heather J. Cordell\, Professor of Statistical Genetics\, Insti
 tute of Genetic Medicine\, Newcastle University
DTSTART:20141121T130000Z
DTEND:20141121T140000Z
UID:TALK51259@talks.cam.ac.uk
CONTACT:Lucy Lloyd
DESCRIPTION:Professor Sylvia Richardson\, Director of the MRC Biostatistic
 s Unit\, will introduce Professor Cordell.\n\nTraditionally\, genetic stud
 ies have focussed on using data from families (related individuals) in ord
 er to track the inheritance patterns of genetic material through a pedigre
 e. In the last few years\, there has been a shift in emphasis towards anal
 ysis of unrelated individuals\, for example in large-scale genome-wide ass
 ociation studies involving population-based cohorts of unrelated cases and
  controls. In this talk I shall illustrate the utility of family-based col
 lections for identifying genetic determinants of complex disease with refe
 rence to three ongoing projects: (1) an investigation of methods/software 
 to correct for relatedness between individuals in genome-wide association 
 studies\, with particular application to a Brazilian family study of visce
 ral leishmaniasis\; (2) linkage/association mapping in an affected sib pai
 r study of vesicoureteric reflux\; (3) improving the power for detection o
 f parent-of-origin effects in case/parent trios through haplotype estimati
 on.\n
LOCATION:Large Seminar Room\, 1st Floor\, Institute of Public Health\, Uni
 versity Forvie Site\, Robinson Way\, Cambridge
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