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SUMMARY:Dissecting translation efficiency through lab evolution\, genome e
 ngineering and inspection of the cancerous genome - Yitzhak Pilpel (Weizma
 nn Institute\, Israel)
DTSTART:20141020T150000Z
DTEND:20141020T160000Z
UID:TALK51350@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:Translation efficiency is determined\, in part\, by the supply
 -to-demand\nrelationships between the tRNA and mRNA pools in cells. To bet
 ter\nunderstand translation we perturb the system through tRNA gene\nmanip
 ulation and recoding open reading frames. We then follow such\nperturbed a
 nd genome engineered bacteria and yeast cells through lab\nevolution and c
 omparative genomics and reveal how evolution acts to adapt\nsupply to dema
 nd. I will also discuss our study of the cancerous tRNA and\nmRNA pools. I
  will show how cancers sustain high translation efficiency\nof genes that 
 carry out cell autonomous\, hence oncogenic\, functionalities.\n\nHosted b
 y Duncan Odom
LOCATION:Cancer Research UK Cambridge Institute\, Lecture Theatre
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