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SUMMARY:TIPP: Taxon Identification and Phylogenetic Profiling - Warnow\, T
  (University of Texas at Austin)
DTSTART:20140324T161500Z
DTEND:20140324T170000Z
UID:TALK51570@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Co-authors: Nam Nguyen (UT-Austin)\, Siavash Mirarab (UT-Austi
 n)\, Mihai Pop (University of Maryland\, College Park)\, Bo Liu (Universit
 y of Maryland\, College Park) \n\nAbundance profiling is a crucial step in
  understanding the diversity of a metagenomic sample. Key to estimating an
  accurate profile is the ability to perform taxonomic identification of th
 e metagenomic reads. Many methods have been developed for taxonomic identi
 fication\, however\, the current best methods often fail to classify many 
 fragments\, especially at lower taxonomic levels. \n\nWe present TIPP (tax
 on identification and phylogenetic profiling)\, a new marker-based taxon i
 dentification and abundance profiling method. TIPP combines a highly accur
 ate phylogenetic placement method (SEPP) with statistical techniques to co
 ntrol the precision and recall of the classification results. We show that
  TIPP is more robust to sequencing error and has better recall than other 
 marker-based taxon identification methods. TIPP also yields highly accurat
 e abundance profiles\, matching or improving on many previous approaches\,
  including NBC\, PhymmBL\, MetaPhyler\, and MetaPhlAn. \n
LOCATION:Seminar Room 1\, Newton Institute
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