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SUMMARY:&quot\;CADD &amp\; ENAC - A bad hand at Scrabble..?&quot\; - Dr Pe
 ter Hunt\, Optibrium Ltd
DTSTART:20140603T131500Z
DTEND:20140603T144500Z
UID:TALK51690@talks.cam.ac.uk
CONTACT:Susan Begg
DESCRIPTION:Cystic Fibrosis is a disease caused by genetic defects in the 
 CFTR protein. The manifestation of those defects in the lung is a reductio
 n in airway hydration producing a viscous mucal  layer and ineffective muc
 ocilliary clearance leading to pathogenic build up in the lungs. The Epith
 elial Sodium channel (ENaC) is instrumental in the osmotic gradients requi
 red for normal airway hydration and can serve as an alternative target for
  the mitigation of CF. The various approaches taken to develop inhibitors 
 of ENaC will be described as well as the recent developments in the struct
 ural elucidation of the related family member ASIC.
LOCATION:Unilever  Lecture Theatre\,  Department of Chemistry
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