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SUMMARY:Molecular subclasses in canine osteosarcoma and mammary cancer - G
 eoffrey Wood\, Associate Professor\, Ontario Veterinary College\, Universi
 ty of Guelph\, Canada
DTSTART:20140604T151500Z
DTEND:20140604T161500Z
UID:TALK51765@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Gene expression changes in tumour cells underlie important asp
 ects of cancer biology\, can aid in prognostication of cancers\, and form 
 the basis for the application of targeted cancer therapies. Understanding 
 which changes are the most clinically relevant is challenging due to the g
 enomic instability of cancers\, the complexity of signalling pathways\, an
 d heterogeneity within tumours and between patients. The approach we have 
 taken is to leverage both the similarities and the differences across mamm
 alian species to investigate changes in gene expression in osteosarcoma an
 d mammary carcinoma. Changes that define molecular subclasses with clinica
 l relevance in human cancers may also have clinical relevance in canine ca
 ncers. Because expression changes that are common across species are likel
 y to reflect biological processes that are fundamental to cancer biology\,
  they may also represent the best molecules for targeted cancer therapies.
 \n\n
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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