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SUMMARY:Cellular self-defense: how cell-autonomous immunity protects again
 st pathogens - Dr Felix Randow\, MRC Laboratory of Molecular Biology
DTSTART:20140507T151500Z
DTEND:20140507T161500Z
UID:TALK51840@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Our prevailing view of vertebrate host defense is strongly sha
 ped by the notion of a specialized set of immune cells as sole guardians o
 f antimicrobial resistance. Yet this view greatly underestimates a capacit
 y for most cell lineages - the majority of which fall outside the traditio
 nal province of the immune system – to defend themselves against infecti
 on. This ancient and ubiquitous form of host protection is termed cell-aut
 onomous immunity and operates across all three domains of life. I will dis
 cuss the organizing principles that govern cellular self-defense and how i
 ntracellular compartmentalization has shaped its activities to provide eff
 ective protection against a wide variety of microbial pathogens. As an ins
 tructive example of cell-autonomous immunity I will illustrate how cells d
 eploy autophagy to protect their cytosol from bacterial invasion. Invading
  bacteria must be specifically recognized to ensure their efficient delive
 ry into autophagosomes. Emphasis will be given to how ‘eat-me’ signals
  become associated with cytosol-invading bacteria\, how cargo-selecting au
 tophagy receptor target cytosolic bacteria for destruction\, and how profe
 ssional cytosol-dwelling bacteria escape from autophagy.
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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