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SUMMARY:GL Brown Lecture: Calcium in the heart: from physiology to disease
  - Professor David Eisner - Institute of Cardiovascular Sciences\, Univers
 ity of Manchester
DTSTART:20140529T150000Z
DTEND:20140529T160000Z
UID:TALK51887@talks.cam.ac.uk
CONTACT:Philipe Mendonca
DESCRIPTION:Calcium is the master controller of cardiac function.  It need
 s to increase on each beat to trigger the heart to contract to pump blood.
   It must fall to low enough levels between beats so that the heart can re
 lax to fill again with blood.  Heart disease\, the major killer world-wide
 \, is associated with abnormal calcium signaling.  \n\nIt is 130 years sin
 ce Sydney Ringer found that calcium is required for cardiac contraction.  
 Enormous progress has been made recently in unraveling the regulation of c
 alcium but there is much left to do.  \n\nIn this lecture I will present a
 n overview of cardiac calcium signaling\, showing how imaging\, electrophy
 siology\, molecular tools and animal models have contributed to our unders
 tanding of the physiology.The first half of the talk will concentrate on t
 he simple\, yet elegant mechanisms that regulate calcium.  The remainder w
 ill focus on abnormal calcium regulation and how this can lead to some of 
 the changes seen in heart failure as well as contributing to the origins o
 f cardiac arrhythmias.  
LOCATION:Main Lecture Theatre\, Physiology Building\, Downing Site
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