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SUMMARY:Self-organisation of pluripotent cells in the mouse embryo  - Prof
 . Magdalena Zernicka-Goetz - Department of Physiology\, Development and Ne
 uroscience and Gurdon Institute
DTSTART:20140612T150000Z
DTEND:20140612T160000Z
UID:TALK51981@talks.cam.ac.uk
CONTACT:Philipe Mendonca
DESCRIPTION:The events at the time the mammalian embryo implants have been
  largely hidden from us - they take pace as embryos embed into the materna
 l tissues.  To overcome this difficulty we have developed a culture system
  for embryos to permit their development at this stage outside the body of
  the mother and allows us to observe these events by time-lapse microscopy
 . This has revealed the first steps in how the pluripotent epiblast cells 
 organise themselves into a structure that will develop into the foundation
  for the body.  This requires cells to respond to signals from underlying 
 basal membrane. Remarkably we can mimic this with a gel of extracellular m
 atrix proteins and get ES cells to undertake the same self-organisation pr
 ocess. Just as a baby needs help to walk\, so the epiblast needs the assis
 tance of the flanking extra-embryonic tissues to guide its development and
  specify the body axes.  Now we wish to understand precisely how these tis
 sues interact to set the embryo on its correct developmental course. 
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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