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SUMMARY:Watching single molecules - Professor David Klenerman FRS\, Depart
 ment of Chemistry\, University of Cambridge
DTSTART:20140516T130000Z
DTEND:20140516T140000Z
UID:TALK52061@talks.cam.ac.uk
CONTACT:Dr Eileen Nugent
DESCRIPTION:For about the last 15 years it has been possible to directly o
 bserve individual molecules in solution\, attached to surfaces or in the m
 embrane of live cells.  My group has focussed on developing these methods 
 and applying them to biological or biomedical problems\, which have been d
 ifficult or impossible to solve using more conventional bulk methods. I wi
 ll firstly introduce   scanning ion conductance microscopy\, which allows 
 nanoscale imaging of live cells and controlled  delivery of molecules to t
 he cell surface. Next I will show how we have developed single molecule fl
 uorescence to detect the interaction of molecules in the test-tube and on 
 cells.  I will then show how these methods can be used to gain new molecul
 ar insights by describing our recent work on T-cell triggering and the rol
 e of proteins aggregates in neurodegenerative disease. 
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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