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SUMMARY:Biomolecular machines on and of DNA - Professor Dr Ralf Seidel\, I
 nstitute for Molecular Cell Biology\, University of Münster\, Germany
DTSTART:20140523T130000Z
DTEND:20140523T140000Z
UID:TALK52062@talks.cam.ac.uk
CONTACT:Dr Eileen Nugent
DESCRIPTION:Cells contain a huge number of complex nanoscale machines. We 
 are interested in deciphering how such machines are functioning on the mol
 ecular level. We use modern single-molecule tools such as magnetic tweezer
 s and fluorescence techniques. This methodology allows to probe single bio
 molecules with force and torque and simultaneously to determine their conf
 ormation and localization. This way the activity of individual enzymes can
  be followed in real-time. We show how we can gain insight into the mechan
 ism of different DNA interacting proteins\, such as helicases\, nucleases 
 and enzymes involved in viral defense. \nIn addition\, we try to use our u
 nderstanding about biomolecular systems to build up artificial nanoscale m
 achines by employing self-assembled DNA nanostructures. Such 3-dimensional
  structures can be used as rigid building blocks. For example\, we apply t
 hem to influence the shape of lipid membranes but also to dictate the grow
 th of inorganic nanoparticles.
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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