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SUMMARY:Determination of protein structures using NMR chemical shifts - Dr
  Michele Vendruscolo\, Dept. of Chemistry
DTSTART:20061109T141500Z
DTEND:20061109T151500Z
UID:TALK5248@talks.cam.ac.uk
CONTACT:Peter Haynes
DESCRIPTION:Chemical shifts are the most readily and accurately measurable
  NMR parameters and they reflect with great specificity the conformations 
 of both native and non-native states of proteins. I will describe a proced
 ure through which chemical shifts can be used to determine the structures 
 of proteins at high resolution and without the need for additional experim
 ental information. The approach involves the use of chemical shifts to gui
 de the assembly of the protein conformation from structural fragments and 
 its refinement through restrained simulations. This strategy should have a
  very\nsignificant impact on the extension of the use of NMR spectroscopy 
 for larger and more complex problems than currently believed to be feasibl
 e.
LOCATION:TCM Seminar Room\, Cavendish Laboratory
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