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SUMMARY:Engineering strategies for tuning cell surface receptor signalling
  - K. Christopher Garcia\, Stanford University School of Medicine 
DTSTART:20140514T151500Z
DTEND:20140514T170000Z
UID:TALK52541@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:In my seminar I will discuss a series of studies from the lab 
 aimed at understanding the relationship between the structure of receptor-
 ligand complexes and signaling. The main focus will be on our efforts to e
 ngineer protein ligands\, using combinatorial biology\, to engage receptor
 s in alternative fashions in order to alter cell subset specificity and/or
  signaling amplitude. We have found that signaling by dimeric cell surface
  receptors\, principally cytokine receptors\, is surprisingly 'tunable' th
 rough ligand engineering.  I will also discuss some recent attempts to app
 ly these principles in a GPCR system.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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