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SUMMARY:From yeast to human patients - a powerful discovery platform for n
 eurodegenerative diseases - Susan Lindquist - Professor of Biology at MIT
DTSTART:20140515T120000Z
DTEND:20140515T130000Z
UID:TALK52599@talks.cam.ac.uk
CONTACT:Sylvie Robinson
DESCRIPTION:Susan Lindquist is a pioneer in the field of protein folding. 
  Her work has provided transforming insights into the role of protein fold
 ing in the evolution of new traits and the devastation of human disease. H
 er seminal work on the role of Hsp90 in folding mutant oncogenic kinases l
 ed to the development of Hsp90-based therapeutics. Her work in fruit flies
 \, mustard plants and yeast established that Hsp90 pervasively influences 
 the manner in which genotypes are read out into phenotypes by chaperoning 
 the folding of key players in signal transduction pathways. This work prov
 ided the first explanation for the rapid evolution of complex traits in re
 sponse to environmental stress. She established the biochemical basis of p
 rotein-based inheritance in yeast and created a new understanding of amylo
 id protein function and assembly. Most recently\, her group has developed 
 new platforms for dissecting the protein-folding problems that drive neuro
 degenerative diseases\, with the aim of discovering new therapeutic strate
 gies based on stopping the precipitating causes of such protein-folding di
 sorders.  Susan Lindquist is a Member and former Director of the Whitehead
  Institute. She is a member of the National Academy of Sciences\, the Amer
 ican Academy of Arts and Science\, the American Philosophical Society\, an
 d the Institute of Medicine. Her honors also include the E.B. Wilson Award
 \, Dickson Prize in Medicine\, the Otto-Warburg Prize\, the Genetics Socie
 ty of America Medal\, the FASEB Excellence in Science Award\, the Max Delb
 rück and the Mendel Medals. In 2009\, she was the recipient of the Nation
 al Medal of Science.  Susan Lindquist is also a member of the Board of Dir
 ectors of Johnson & Johnson\, and a co-founder of FoldRx\, a biotech compa
 ny (recently acquired by Pfizer) that develops drug therapies for diseases
  of protein misfolding and amyloidosis. She became an Investigator of the 
 Howard Hughes Medical Institute in 2006. Previously she was on the faculty
  of the University of Chicago where she was the Albert D. Lasker Professor
  of Medical Science. She received her PhD in Biology from Harvard Universi
 ty\, and was a postdoctoral fellow of the American Cancer Society at the U
 niversity of Chicago.
LOCATION:CRUK Cambridge Research Institute - LiKa Shing Centre - Robinson 
 Way - Cambridge - CB2 0RE
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