BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Genome stability and instability during repair of a broken chromos
 ome - Jim Haber\, Director\, Rosenstiel Basic Medical Sciences Research Ce
 nter
DTSTART:20141106T161500Z
DTEND:20141106T180000Z
UID:TALK52784@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Double-strand breaks in DNA pose a serious threat to genome in
 tegrity.  Such breaks can be repaired by nonhomologous end-joining\, which
  often results in alterations of DNA sequence\, or by homologous recombina
 tion in which the DSB is repaired by using an intact\, identical or nearly
  identical sequence as a template.  However\, even DSB repair by gene conv
 ersion is associated with a highly elevated risk of associated mutation.  
 Such mutations often have a "signature" associated with slippage or templa
 te switching of the repair DNA polymerases.  We show that pairs of such sl
 ippage events can occur as often as once every 100 repair events.  Similar
  template switching is found in another DSB repair mechanism\, termed brea
 k-induced replication.  These types of instability my underlie some of the
  complex rearrangements seen in human developmental diseases or in cancer 
 cell chromosomes exhibiting chromothripsis.  The role of chromatin in DSB 
 will also be discussed. 
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
END:VEVENT
END:VCALENDAR