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SUMMARY:Reward Inference by Prefrontal and Striatal neurons and their inte
 raction - Prof. Masamichi Sakagami - Tamagawa University Brain Science Ins
 titute
DTSTART:20140530T150000Z
DTEND:20140530T160000Z
UID:TALK52797@talks.cam.ac.uk
CONTACT:Philipe Mendonca
DESCRIPTION:The brain contains multiple yet distinct systems involved in r
 eward prediction. To understand the nature of these processes\, we recorde
 d single-unit activity from the lateral prefrontal cortex (LPFC) and the s
 triatum of monkeys performing a reward inference task using an asymmetric 
 reward schedule. Prefrontal neurons inferred the reward value (amount) of 
 a stimulus\, even when the monkeys had not yet learned the stimulusreward 
 association directly. Striatal neurons\, however\, predicted the reward fo
 r the stimulus only after directly experiencing the stimulus-reward contin
 gency. Our results suggest dissociable functions in their reward predictio
 n\, i.e.\, that the LPFC utilizes stimulus categorization in a generative 
 process of reward inference\, whereas the striatum applies direct experien
 ces of stimulus-reward associations in the guidance of behavior. However\,
  while the LPFC and striatum have mutual connections through direct and in
 direct pathways\, it is not clear that how the two structures are interact
 ive to make a reward prediction. To investigate this issue\, we simultaneo
 usly recorded local field potential (LFP) from the both areas during monke
 y's performing the reward inference task and performed the Granger-causali
 ty analysis with the LFP data. Information flow from LPFC to striatum was 
 larger than that from striatum to LPFC\, particularly in correct trials\, 
 in trials with new stimulus and in small reward trials.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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