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SUMMARY:Sonocytology: Manipulation and Sensing Particles - Dr Anne Bernass
 au\, University of Glasgow
DTSTART:20140612T100000Z
DTEND:20140612T110000Z
UID:TALK52810@talks.cam.ac.uk
CONTACT:Dr Eileen Nugent
DESCRIPTION:The ability to manipulate cells and other micro-particles in a
  completely biocompatible and dexterous manner is critical for numerous bi
 ological studies and applications such as cell-cell communication\, biosen
 sing\, tissue engineering\, and regenerative medicine. Here we present an 
 “acoustic manipulators” technique that utilises acoustic standing wave
 s to manipulate particles\, cells\, and micro-organisms non-invasively. Wi
 th its advantages in biocompatibility\, miniaturization\, and versatility\
 , the acoustic manipulators presented here will become a powerful tool for
  many disciplines of science and engineering.\nThe acoustic manipulator de
 vice consists of multiple ultrasound transducers electronically driven in 
 an independent fashion. A suspension of microparticles or cells is infused
  into the cavity. A radio frequency (RF) signal is applied to transducers 
 opposite of each other to generate two   acoustic counter propagating wave
 s. The interference of these two series of acoustic propagating waves form
 s a standing wave\, as well as a periodic  distribution of pressure nodes 
 (with minimum pressure amplitude) and antinodes (with maximum pressure amp
 litude) in the medium\, causing pressure fluctuations. These fluctuations 
 lead to acoustic radiation forces that act on the suspended particles\, mo
 ving them to the pressure nodes or antinodes (depending on their mecano el
 astic properties) in the acoustic standing field.\nOur acoustic manipulato
 rs are capable of manipulating cells and micro-with precision and dependin
 g their mechanical properties. Cell viability\, proliferation\, and apopto
 sis studies have revealed the technique to be perfectly biocompatible. Add
 itionally\, the ability to massively move particles with great speed could
  make this technique a key tool in many high-throughput assays such as cel
 l sorting and separation. The aforementioned advantages\, along with this 
 technique’s simple design and ability to be miniaturized\, render the 
 “acoustic manipulator” technique a promising tool for various applicat
 ions in biology\, chemistry\, engineering\, and materials science.
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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