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SUMMARY:Getting to grips with the metabolic network of Arabidopsis - Dr Le
 e Sweetlove\, University of Oxford
DTSTART:20061102T160000Z
DTEND:20061102T170000Z
UID:TALK5286@talks.cam.ac.uk
CONTACT:3901
DESCRIPTION:Of all the molecular-interaction networks in plants\, metaboli
 sm is by far and away the most completely described both in terms of netwo
 rk topology and in terms of the properties of its molecular components. Mo
 reover\, experimental tools now exist that allow systematic measurement of
  its behaviour. The construction of a mathematical model that encapsulates
  the metabolic network of plants at 'genome scale' is therefore a plausibl
 e goal (especially in the case of model plants such as Arabidopsis). Howev
 er\, although genomic information provides a starting point in establishin
 g a consensus metabolic network topology\, a great deal of experimental in
 put will also be required. This will include transcriptomic / proteomic da
 ta to constrain the model to those enzymes actually present under a given 
 condition as well as metabolic flux maps to validate the model output. The
  importance of the integration of experimental data into models will be di
 scussed and examples will be given to show how different experimental stra
 tegies can be used to provide information about the regulatory structure w
 ithin the metabolic network.\n\nhttp://dps.plants.ox.ac.uk/external/
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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