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SUMMARY:Computational Neuroscience Journal Club - Johannes Friedrich ( CBL
 \,  Cambridge University\, Engineering Dept.)
DTSTART:20140617T150000Z
DTEND:20140617T160000Z
UID:TALK53053@talks.cam.ac.uk
CONTACT:Guillaume Hennequin
DESCRIPTION:Johannes Friedrich will cover:\n\nPartitioning neuronal variab
 ility\n\nRobbe L T Goris\, J Anthony Movshon & Eero P Simoncelli\n\nNature
  Neuroscience (2014)\n\nhttp://www.nature.com/neuro/journal/v17/n6/full/nn
 .3711.html\n\nResponses of sensory neurons differ across repeated measurem
 ents. This variability is usually treated as stochasticity arising within 
 neurons or neural circuits. However\, some portion of the variability aris
 es from fluctuations in excitability due to factors that are not purely se
 nsory\, such as arousal\, attention and adaptation. To isolate these fluct
 uations\, we developed a model in which spikes are generated by a Poisson 
 process whose rate is the product of a drive that is sensory in origin and
  a gain summarizing stimulus-independent modulatory influences on excitabi
 lity. This model provides an accurate account of response distributions of
  visual neurons in macaque lateral geniculate nucleus and cortical areas V
 1\, V2 and MT\, revealing that variability originates in large part from e
 xcitability fluctuations that are correlated over time and between neurons
 \, and that increase in strength along the visual pathway. The model provi
 des a parsimonious explanation for observed systematic dependencies of res
 ponse variability and covariability on firing rate.\n
LOCATION:Cambridge University Engineering Department\, CBL Rm #438 (http:/
 /learning.eng.cam.ac.uk/Public/Directions)
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