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SUMMARY:Bionanoscience for Innovative Global  Healthcare Research &amp\; T
 echnology  (BIGHEART) - Prof. Luke P. Lee\, Berkeley Sensor and Actuator C
 enter\, California Institute of Quantitative Biosciences\, UC Berkeley
DTSTART:20140708T133000Z
DTEND:20140708T143000Z
UID:TALK53353@talks.cam.ac.uk
CONTACT:Jerome Charmet
DESCRIPTION:It is critical time to solve the problems of both developed an
 d developing world healthcare challenges. In the first part of talk\, I wi
 ll present an external optical manipulation of genetic circuits for the fu
 ndamental understanding of gene regulation in human biology and precision 
 medicine. High-precision NIR optical controls of nanoplasmonic optical ant
 ennas allow remote gene regulations in living cells. Since the abnormal NF
 -κB signaling pathway has been associated in cancer\, infectious diseases
 \, inflammation\, and neurological diseases\, we found a solution for the 
 spatiotemporal regulation of NF-κB activation by the selective optical li
 berations of IκB siRNA and p65 siRNA from biophotonic antennas. The effic
 acy of multistep bidirectional control of specific gene expression was dem
 onstrated through the expression measurements of IP-10 and RANTES activate
 d by nuclear p65.   \n\nIn the second part of talk\, I will discuss integr
 ative molecular diagnostic systems (iMDx). The iMDx comprises a self-conta
 ined sample preparation from whole blood\, multiplexed protein assays\, an
 d nucleic acid amplification assays on chip with a sample-to-answer readou
 t platform. As we gain more insight into the genomic basis of pathogen inf
 ectivity and drug resistance\, point-of-care nucleic acid testing will lik
 ely become an important tool for global health. Additionally\, the iMDx fe
 atures cell phone data connectivity and GPS sample geotagging\, which can 
 enable epidemiological surveying and remote healthcare delivery. In summar
 y\, I will share my vision for the convergence of art\, culture\, technolo
 gy and science (ACTS) to transform life sciences and healthcare.  Creative
  ACTS will allow us to find the solutions for preventive precision medicin
 e and low-cost healthcare systems.
LOCATION:Kapitza Building Seminar Room 16\, Cavendish Laboratory\, Departm
 ent of Physics
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