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SUMMARY:Regenerating the brain - from mechanisms to medicines - Professor 
 Robin Franklin\, Wellcome Trust-MRC Cambridge Stem Cell Institute\, Univer
 sity of Cambridge
DTSTART:20141014T151500Z
DTEND:20141014T161500Z
UID:TALK53374@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Remyelination\, the process by which new myelin sheaths are re
 stored to demyelinated axons\, represents one of the most compelling examp
 les of adult multipotent progenitor cells contributing to regeneration of 
 the injured CNS. This process can occur with remarkable efficiency in mult
 iple sclerosis (MS)\, and in experimental models\, revealing an impressive
  ability of the adult CNS to repair itself. However\, the inconsistency of
  remyelination in MS\, and the loss of axonal integrity that results from 
 its failure\, makes enhancement of remyelination an important therapeutic 
 objective. There is now compelling evidence that ageing is the major contr
 ibutor to the declining efficiency of remyelination and that this is large
 ly due to a failure of stem cell differentiation. This talk will review re
 cent studies we have undertaken aimed at obtaining a detailed understandin
 g of the mechanisms of regulating differentiation during remyelination in 
 different populations of adult CNS progenitor cells.
LOCATION:Lecture Theatre 1 - Department of Veterinary Medicine
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