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SUMMARY:Microbiota-host interplay in the intestine and its impact on healt
 h and disease   - Prof Jerry Wells\, Chair - Host-Microbe-Interactomics Gr
 oup University of Wageningen
DTSTART:20150603T150000Z
DTEND:20150603T160000Z
UID:TALK53376@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:The coevolution of a mutualistic relationship between the host
  and the microbiota required specialized adaptations of the mucosal immune
  system to tolerate the intestinal bacteria and contain them in the lumen 
 while remaining responsive to pathogen colonization and invasion. Neverthe
 less commensal microorganisms are not ignored and can signal to epithelial
  cells and interact with immune cells in the mucosa to influence the activ
 ity of the immune system. The host innate and adaptive immune responses al
 so regulate the structure and composition of the intestinal microbiota\, l
 eading to a homeostatic balance. This Lecture will highlight recent advanc
 es in our understanding of this complex interplay and specific microorgani
 sms that perform functions important for host physiology and homeostasis. 
 The disruption of this balance is marked by dysbiosis and disturbances in 
 the mucosal immune system and barrier function\, which could have pathogen
 ic outcomes.  I will present examples of the role of microbiota in inflamm
 atory diseases and therapeutic potential of 'cornerstone' species or micro
 bial consortia to prevent or treat diseases. \n\n
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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