BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Understanding Mechanisms of Sterile Inflammation - Dr David Brough
 \, Faculty of Life Sciences\, University of Manchester
DTSTART:20141112T161500Z
DTEND:20141112T171500Z
UID:TALK53379@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Inflammation is an essential host response to infection and in
 jury. At the heart of inflammation research is an attempt to understand th
 e regulation of the pro-inflammatory cytokine interleukin-1β (IL-1β)\, w
 hich is central to host responses to infection\, but also causes tissue in
 jury when activated inappropriately. IL-1β is produced by many cell types
  as an inactive precursor (pro-IL-1β) and requires processing by the prot
 ease caspase-1 to obtain full biological activity. Caspase-1 is also produ
 ced as a precursor and becomes activated following recruitment to an intra
 cellular multi-molecular scaffold called an inflammasome. Multiple inflamm
 asomes are described\, each defined by the presence of a cytosolic pattern
  recognition receptor (PRR). The PRR NLRP3 forms an inflammasome that driv
 es the inflammatory response to pathogens such as Staphylococcus aureus or
  Listeria monocytogenes\, but is also known to drive damaging inflammation
  during sterile inflammatory insults. The goal of my research is to unders
 tand the mechanisms regulating the production of IL-1 and how they contrib
 ute to disease. \n \n
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
END:VEVENT
END:VCALENDAR