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SUMMARY:Dopamine Neuron Regulation and its Disruption in Schizophrenia and
  Depression - Anthony A. Grace\, Ph.D.  Distinguished Professor of Neurosc
 ience\,  Professor of Psychiatry and Psychology\,  Department of Neuroscie
 nce\, University of Pittsburgh  Pittsburgh\, USA
DTSTART:20141017T140000Z
DTEND:20141017T153000Z
UID:TALK53477@talks.cam.ac.uk
CONTACT:Louise White
DESCRIPTION:The dopamine-containing neurons of the midbrain have been impl
 icated in a broad array of psychiatric disorders\, ranging from schizophre
 nia to drug abuse and depression. Dopamine neurons recorded in vivo are kn
 own to exhibit different functional activity states\, including baseline t
 onic firing and phasic activation in response to salient stimuli.  The bal
 ance between tonic and phasic firing is regulated by multiple brain region
 s\, including the hippocampus\, the amygdala\, and the prefrontal cortex. 
  Electrophysiological and behavioral studies in animal models of psychiatr
 ic disorders\, as well as human imaging studies in patients\, suggest that
  disruption to this balance may underlie psychiatric symptoms such as psyc
 hosis and anhedonia.  This type of information can contribute both to a be
 tter understanding of the pathophysiology of major psychiatric disorders\,
  as well as glean insights into novel avenues of treatment.\n
LOCATION:Ground Floor Lecture Theatre\, Department of Psychology
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