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SUMMARY:GIMAP5 and cell survival – questions and more questions - Prof. 
 Sheela Ramanathan\, Department of Pediatrics\, Immunology Division - Unive
 rsité de Sherbrooke\, Canada 
DTSTART:20140905T130000Z
DTEND:20140905T140000Z
UID:TALK53722@talks.cam.ac.uk
CONTACT:Matthew Humphries
DESCRIPTION:Mature T lymphocytes undergo spontaneous death in the biobreed
 ing diabetes-prone strain of rats due to the loss of functional GIMAP5 (GT
 Pase of the immune associated nucleotide binding protein 5) protein. In mi
 ce GIMPA5 deficiency compromises the survival capacity of hematopoietic st
 em cells and mature lymphocytes. The detailed mechanisms underlying the pr
 o-survival function of GIMAP5 is not known. We have previously shown that 
 GIMAP5 deficiency impairs TCR-induced calcium influx. We have also shown t
 hat this reduced calcium influx is associated with the inability of mitoch
 ondria to sequester calcium in a microtubule dependent manner. The possibl
 e mechanisms involved in the regulation of cellular calcium response will 
 be discussed.
LOCATION:The Babraham Institute - The Brian Heap Seminar Room
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