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SUMMARY:Updating The Two Signal theory of T cell Activation with a Cellula
 r Calculus - Phil Hodgkin\, Walter and Eliza Hall Institute\, Melbourne 
DTSTART:20141205T130000Z
DTEND:20141205T140000Z
UID:TALK53860@talks.cam.ac.uk
CONTACT:Dr Tennie Videler
DESCRIPTION:Updating The Two Signal theory of T cell Activation with a Cel
 lular Calculus\n\nPhilip D. Hodgkin1\,2\, Julia M. Marchingo1\,2\, Mark R.
  Dowling1\,2\, Andrey Kan1\,2\,  Ken R. Duffy3\nSusanne Heinzel1\,2\, \n\n
 1The Walter and Eliza Hall Institute of Medical Research\, Melbourne\, Vic
 toria\, Australia\; 2The University of Melbourne\, Melbourne\, Victoria\, 
 Australia\n3Hamilton Institute\, National University of Ireland\, Maynooth
 \, Ireland.\n\nT and B-lymphocytes process affinity\, co-stimulatory signa
 ls\, and secreted cytokines to reach decisions about the strength and type
  of response to follow after challenge. By combining direct cell imaging\,
  genetic manipulation and computer modelling we examine cells making decis
 ions under different stimulation combinations. Our results reveal surprisi
 ngly simple rules for cellular calculation for both B and T cells.  Typica
 lly cells simply count through a series of divisions\, stop and die.  Vary
 ing the stimulation strength alters the proportion of cells entering the a
 utonomous program without changing division\, differentiation or survival 
 rates. In T cells IL-2 extends the number of divisions reached in a concen
 tration dependent manner without altering time between divisions.  These r
 esults give an insight into how complex immune responses evolved from simp
 ler pathways and suggest a signal integration calculator can be developed 
 to dissect the influence of changes caused by drugs\, or genetic polymorph
 isms.\n
LOCATION:MPLT\, MRC-LMB\, Francis Crick Avenue\, Cambridge Biomedical Camp
 us\, CB2 0QH
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