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SUMMARY:Regulation of Notch signalling by the endosomal pathway. - Profess
 or Dr. Thomas Klein\, Institute of Genetics\, Heinrich-Heine-Universität 
 Düsseldorf
DTSTART:20141106T143000Z
DTEND:20141106T153000Z
UID:TALK54024@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Lethal (2) giant disc (Lgd) belongs to a protein family that i
 s present in all metazoans and involved in endosomal trafficking of transm
 embrane and secreted proteins. Loss of its function results in the activat
 ion of the Notch signalling pathway in a ligand independent manner. In my 
 seminar I will discuss in which endosomal process Lgd is involved\, which 
 other signalling pathways might be affected and how the Notch pathway is a
 ctivated upon loss of function of lgd.
LOCATION:Part II Room\, Department of Genetics
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